May Chronic Treatment with Proton Pump Inhibitors Increase Risk of Fracture Resulting from Osteoporosis Free Essay Example, 3000 words

Inhibitors (PPIs) have become one of the most commonly prescribed classes of medications in the primary care setting. 14 Their ability to enable practitioners to simply and effectively treat a variety of acid-peptic diseases with minimal side-effects has placed PPIs among the major advancements in dealing with gastric conditions and disorders. Omeprazole (Prilosec) was introduced to the United States market in the year 1989, and its rapid success and longevity have led to several other PPI drug becoming readily available by prescription in the United States. The intravenous form of pantoprazole (Protonix I. ) is now available, and the U. Food and Drug Administration (FDA) approved one of the newest PPI, esomeprazole (Nexium), in 2001. Osteoporosis is a common condition throughout the developed world, affecting up to 16% of women and 7% of men aged 50 years and older. The condition is of primary concern because of the increased incidence of fractures caused by bone degeneration. 1 Th e normal amount and variety of proteins and minerals in the bone is altered in cases of osteoporosis, and the standard the bone mineral density (BMD) is reduced, disrupting the bone microarchitecture itself and contributing to its structural failure. We will write a custom essay sample on May Chronic Treatment with Proton Pump Inhibitors Increase Risk of Fracture Resulting from Osteoporosis or any topic specifically for you Only $17.96 $11.86/page The three fracture sites said to be typical of fragility fractures are vertebral fractures, fractures of the neck of the femur and Colles fracture of the wrist.